"The fourth-seeded Federer knows what to expect against Isner as he likened Sunday's looming contest to a football shoot-out". Isner used it to great effect in his 7-6 (7/3), 7-6 (7/4) win over Shapovalov's friend and compatriot Felix Auger-Aliassime earlier in the day, smashing down 21 aces.
Shapovalov hit 14 unforced errors in the opening four games and when the 37-year-old Federer was handed another break after a double-fault, the world number 23 trudged back to his chair with his head bowed.
It was the biggest age gap between opponents in the quarter-finals or later of an ATP Masters 1000 and the biggest gap in Federer's career.
The 19-year-old came out stronger for the second set and, after holding serve, looked to be on his way to breaking Federer for the first time.
The 20-time Grand Slam Champion has defeated the sixth-seeded Anderson by 6-0,6-4 while Shapovalov defeated American young gun Frances Tiafoe by 6-7 (5/7), 6-4, 6-2 in his last match.
"For me I'll be the goalie, I'll try my very best".
It is the third consecutive year that Federer has led the Race after the "Sunshine Double". I know what to expect when I play John, he's got an fantastic serve so it's going to be tough for sure. "I couldn't put a second serve in anymore".
After five good holds in the second set, Andre gained the lead with a break at 30 following a loose backhand from Roger, increasing the advantage with a service victor in the seventh game and clinching the set thanks to a good hold at 5-3, moving a set away from the title some 70 minutes after the beginning of the encounter.
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"The biggest lesson was to stay in the present and believe in yourself, because you can always dig deep and find resources within yourself", Auger-Aliassime said of his run.
Shapovalov's ranking will move to No. 20, making him only the second Canadian in the 45-year history of the ATP's computer rankings - after Milos Raonic in 2012 - to enter the top-20.
"For sure (it was) nerves", said Auger-Aliassime about his serving woes.
Canada will not be starved for representation in the semifinals of the Miami Open.
"I felt this couple of times when playing these guys and I think it's a bit unfair". "Secondly you want to get in a neutral position, which is very hard, because you know he's looking for his forehand or he looks to come in or try to take charge of the point". "I was just trying to play as good as I can, but he played an excellent match".
In conclusion, Roger Federer said, "But I still think they all will be back this year at some point, hopefully, and the year-end hopefully will be incredibly exciting".
Isner played much better in the second set, but in the end the pain became too much for him to mount an effective defence.
"It was just important to keep on doing what I was doing, and if he's hurt, well, then so be it, and bad luck for him", Federer said.