The Grammy-nominated artist, born Ermias Asghedom, was in town last November for "Wake UP and Vote".
Jay-Z and Nipsey Hussle attend the PUMA x Nipsey Hussle 2019 Grammy Nomination Party.
The Los Angeles Police Department said in a statement that a shooting was reported about 3:20 p.m. PDT in the area of Slauson Avenue and Crenshaw Boulevard, and that three victims were transported to a hospital where one was pronounced dead.
The 33-year-old was often spotted court side while attending LA Lakers games, himself being a native of the LA neighborhood Crenshaw.
According to the Los Angeles Times, the shooter was a young man known to Nipsey who opened fire at close range before fleeing in a getaway vehicle. More details will be available when a full autopsy report is released.
Hussle had always been associated with the Rollin 60s Neighborhood Crips, one of Los Angeles' largest street gangs.
Hussle's Facebook profile stated that he was a "devout member" of LA street gang "Rolling Sixty Crips".
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Notable figures from the music industry, including Cardi B, Rihanna, Drake, Talib Kweli, A$AP Rocky, 21 Savage and many more have paid tribute to the late artist. A few men who were there with Nipsey ran away from the scene when the gunfire started, and you can see at least one man fell to the ground.
He had since become a community organiser, according to media reports.
He is survived by his two children and his girlfriend, Lauren London, who just gave birth to their son Kross in 2016.
"I know how much we put into the album, so to get to be recognized, it means a lot for me, my team also, everyone who worked on it, and [we're] just excited to be here", he said.
In a tweet Sunday, Los Angeles Police Commissioner Steve Soboroff said he and LAPD Chief Michel Moore were set to meet with Hussle Monday at the rapper's request "to talk about ways he could help stop gang violence and help us help kids".