Early damage reports from the storm includes downed trees and limbs, standing water in roadways, according to tweets from the Lexington County Sheriff's Department.
A series of tornado warnings along the Georgia-Alabama border was issued by the National Weather Service on Sunday.
Large-scale search and rescue operations have been launched in Lee County, where officials reported multiple injuries. Beauregard is a community about 60 miles (95 kilometres) east of Montgomery, Alabama's capital city. But emergency crews and others said they would be out through the night coping with the devastation left behind.
Selma, Alabama, where crowds had gathered to mark the anniversary of "Bloody Sunday", the 1965 civil rights march incident, suffered thunderstorms, Norman said, but no tornadoes. Both were under tornado warnings on Sunday.
At least 14 people, some of them children, have died after a tornado swept through Lee County in Alabama. Trees all around had been snapped bare of branches.
The deaths and injuries occurred in the community of Beauregard in Lee County, an area in the eastern part of the state near the Georgia line, Rita Smith with the Lee County Emergency Management Agency told The Associated Press. "We're going to be here all night".
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She said searches of damaged homes and structures had turned up no serious injuries or deaths.
Six people suffered injuries, with the most severe being a possible broken leg, she said.
Shortly after that, a separate storm caused damage in Peach and Crawford counties, just west of Macon.
The National Weather Service confirmed a tornado by radar that toppled trees in Walton County, Florida, located in the Panhandle. "And when you have a mature line of storms moving into an area where low level winds are very strong, you tend to have tornadoes developing. It's a favorable environment for tornadoes".
He says the threat of more tornadoes will continue for several hours as the storm system races toward the Atlantic seaboard. The tornado watch also covers a large area of SC, including the cities of Charleston and Columbia.