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TWO people have tragically died and two others have been injured after a plane crashed into a house in the United States.

"OC Coroner working to positively identify the decedents and notify next of kin, no additional info at this time", the department said in a tweet. Fire officials say two people were treated in hospital for burns.

The Orange County Fire Authority said crews were responding to two homes.

Pat Rogers, who lives about a mile from the crash site, told the Orange County Register he saw the plane on fire and coming apart.

The Federal Aviation Administration said the twin-engine Cessna 414A crashed in Yorba Linda shortly after taking off from the Fullerton Municipal Airport.

"A plane crashed in my neighborhood..."

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Twitter user Joshua Nelson wrote, "A few houses down [from the crash] the propeller and engine landed in their yard".

No other information was immediately available.

"I come out.it's raining plane parts from the sky", Jared Bocachica told the affiliate station.

Yorba Linda is located about 33 miles southeast of Los Angeles. Viewers can see a man drenching it with water from a garden house. The fire spread to a SUV that was parked in the driveway. "They also said that only the pilot was on board the aircraft".

The National Transportation and Safety Board will investigate the cause of the crash.