Manchester United have won 10 of their 11 games under the Norwegian and continued their fine form with a 3-0 win over Fulham at Craven Cottage on Saturday.
"I imagine United will be very bold, play a lot of attack-minded players", he said.
"We will not change our approach just because of these absences".
"But it gives other players a chance and maybe they are more unpredictable for us with who they are going to play".
"He has wonderful qualities, he can do a lot of things, extremely strong, with the ball at his feet, he's very good and very strong in challenges and one on ones, taking people on he's always capable of making a difference".
Tuchel added that it was wrong to expect Kylian Mbappe to make up for the injured South American pair.
"In any case, we must wait a bit more as the exams are still ongoing".
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Manchester United fans are conflicted about which central defender their club should sign over the summer transfer window. I hope it continues into the future and let's hope that together, we can win trophies and silverware".
"We need to raise our level of performance, concentration, raise our level in duels, but I know we can do it, and we will do it". I want for us to be able to help him by finding him with good passes. "It wasn't the best period of my career, or they didn't let me have my best time there", Di Maria said in a recent interview with radio station France Bleu.
Draxler is unsure if he will start but feels ready for whatever role Tuchel might have in mind for him and does not see himself as a Neymar replacement. I think that the news will not be very good. "We can not replace him and now we miss another key player in Edi".
"He has wonderful qualities, he can do a lot of things, extremely strong, with the ball at his feet, he's very good and very strong in challenges and one on ones, taking people on he's always capable of making a difference and I think in my opinion he's always risky offensively with Martial, they're a very unsafe pairing".
There has been a real buzz around Old Trafford since the "Baby-faced Assassin" took over, lifting the doom and gloom that surrounded Mourinho in his final days.
Ole's at the wheel, and nobody - not even Mauricio Pochettino - looks like a better candidate at this moment in time. "I think Manchester United have the advantage".
Marouane Fellaini's departure from Manchester United marked the end of a painful era for many United fans with the big Belgian coming to the club under former boss David Moyes. "I say thank you for all the emotion that the Champions League has given me".