In it, she pays tribute to some of her favorite movies - Mean Girls, 13 Going on 30, Legally Blonde, and Bring It On.
Here are five things to know about the five-and-a-half-minute video, which the singer teased fans with for weeks.
Keeping with the early millennium vibe, Grande then jumps to Bring It On, where, along with her Victorious co-star Matt Bennett, she recreates the teeth brushing scene from the cheerleading classic.
Bennett tells us Daniel - who plays Damian, Lindsay Lohan's friend in the movie - had to pass on the offer because he's now on a comedy tour.
Legally Blonde's Jennifer Coolidge - portrayed as Paulette Bonaforte - was also seen giving sound advises in the song.
Warning: There is strong language in the music video below.
And last but not least we have Reese Witherspoon, star of the heavenly film Legally Blonde.
10 best moments from Ariana Grande’s Thank U, Next video
BTW. Bennett got to include his new "Mean Girls" parody cookbook in the music video, titled "The Burn Cookbook". "We have nothing left".
Firstly, Mean Girls gave Grande the greatest honour of all. During the "bend and snap" portion, a mail delivery man shows up to dance with Coolidge, but instead of UPS, the patch sewn onto his uniform says "BDE", yet another Penis Davidson joke (BDE stands for big d- energy, and it originally came from a Twitter thread describing Davidson's confident demeanor).
It features Mean Girls' "army trousers and flip flops" girl (aka Bethany Byrd) and the singer Troye Sivan - but what is the opening sequence actually about?
So did the Mean Girls handle. In the video, she pastes a photo of her and former fiance Pete Davidson (with parts of his face covered in purple hearts) into the book, and writes "sry I dipped" on the page.
NASA InSight mission successfully lands on Mars
The round, dome-shaped seismometer will sit on the surface and sense vibrations, or, as they're known on Mars, Marsquakes. The image shows the landscape of the Elysium Planitia, which is a large plain that's located at the equator of Mars.