Status Orange weather warnings have been issued for 13 counties which are expected to bear the brunt of the storm.
An amber warning for heavy rain has been issued for most of south Wales on Friday, as Storm Callum approaches.
A yellow wind warning is also in place for Carlow, Kildare, Kilkenny, Laois, Longford, Offaly, Westmeath, Cavan, Monaghan, Leitrim, Roscommon, Limerick and Tipperary.
Rainfall is expected to reach up to 10cm and could cause flooding, as well as making driving conditions hard for those affected.
Cork and Kerry are also affected by the status orange wind warning, but those counties have been advised to adhere to the warning between 10pm tonight and 9am in the morning.
The Met Office said that "leaves and twigs, brought down by the wind, could block drains and culverts, increasing the likelihood of flooding".
Areas of high ground could see over 60 mm of rain in 12 hours with some exposed locations seeing as much as 100 mm by the end of the day.
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Strong winds associated with Storm Callum, coinciding with high spring tides, will affect Ireland on Thursday night and Friday morning. "You can check our website or call Floodline on 0345 988 1188 for any flood warnings that may be in place and keep an eye on weather reports and local news for details of any disruption in your area".
Richard Brown, Pembrokeshire County Council's Head of Environmental Services and Public Protection, said that although Council staff would be working continuously to clear the roads, motorists would need to be vigilant.
From midnight on Saturday, weather experts have warned of yet more "heavy and persistent" rainfall across the city.
"We are advising people to avoid coastal areas during this event".
Ireland will bear the brunt of the storm, but gusts of 80mph are expected in parts of Scotland, with up to 10cm of rain falling.