Ronaldo has since scored two goals in his first five appearances for Juventus and was sent off on his Champions League debut for the club on Wednesday night.
Espanyol head to Madrid in fourth place, just three points behind Los Blancos and Lopetegui is in no doubt about the challenges facing his side.
"Espanyol played well and were organised, and we knew it would be hard", said Lopetegui, who remains unbeaten in LaLiga since replacing Zinedine Zidane in the summer.
"It was a game we had marked in red because of the quality of the opposition, who had the whole week to prepare for the game. We played as a team".
Zidane guided Madrid to an unprecedented three successive Champions League titles in less than three years at the helm, opting to step down a few days after completing the hat-trick in May.
Reigning champions Real were 2-0 up after 58 minutes through Isco and Gareth Bale before Mariano Diaz sealed the win over last year's semi-finalists in injury time.
San Antonians react to first debate between Cruz, O'Rourke
His family says they're doing the same. "Nobody should be in their own home and shot and killed in their own home", Cruz said. O'Rourke supports people's rights to "take a knee", which he believes is a peaceful way to protest racial injustice.
"You will get the lineup tomorrow".
Santos starlet Rodrygo Goes, who is to join Real Madrid in 2019, has spoken to FourFourTwo about his forthcoming arrival at the Bernabéu.
Isco, Gareth Bale and returning striker Mariano Diaz were on the scoresheet for Real Madrid with a win ensuring the flawless start to their defence of the Champions League title.
"They lost a great champion, but they have many other champions in the squad who can compensate his departure".
"I wasn't nervous at all when they started to criticise us two weeks ago, as if everything was lost and we were dead, and now we are the best in the world", said Atletico defender Juanfran.
"We will not go to the United States", Perez told Madrid's general assembly on Sunday.