They face Spain in the first match of the new competition; the Nations League, a tournament that has left even the players bemused.
Barcelona's Sergio Busquets starts but he's the only player from the La Liga champions in the side, with Sergi Roberto named on the bench.
Spain manager Luis Enrique is trying to do anything he can to keep his squad focused and one of the things he has told his players is that there will be no more board games and PlayStation. I'm not going to be affected by that at all.
"The fact we have been a reference over the past decade means that everyone knows our national team", said Luis Enrique. Spain got crashed out of the World Cup after being defeated in penalties against hosts Russian Federation.
Ramos said that it was the job of the current squad to restore Spain to the heights that saw them triumph in three consecutive worldwide tournaments - the European championships of 2008 and 2012 and the World Cup of 2010.
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But the pair insist there is no bad blood between them as they work together for the first time, with Ramos keen to move Spain forward. I am convinced that is what we will do.
The head coach refused to discuss any tactics ahead of the match against England, which finished fourth at this summer's World Cup, saying he did not want to give the opponent "any kind of clues".
The coach appears to be taking a hard line to try to get "La Roja" back on track after its recent setbacks, imposing strict new rules that include a cellphone ban during meals.
Ramos is likely to receive a dodgy reception from England fans, especially those of a Liverpool persuasion at Wembley but little has fazed the 32-year-old during his career and he is sticking by his story.
Salah injured his shoulder and had to leave the game after falling under a heavy challenge from Ramos as Real went on to win 3-1.