Ten years on from that remarkable contest, which is widely considered as "the greatest ever tennis match", Nadal was again celebrating another All England Club success with the same broad match details.
Then, at 4-3, they played an epic 18-point game that featured six deuces and another trio of break points for del Potro, none of which he managed to convert.
World number one Rafael Nadal says he will have to be at his very best when he faces Novak Djokovic in Friday's much-anticipated Wimbledon semi-final. "I tried to resist and maintain focus". "It's a day to be happy".
"Rafa is a fighter and he has a fantastic game".
Beyond dispute, Anderson's ultimate performance and recovery on this occasion was the antithesis of a choker, prompting the unequivocal praise from the usually deceptive and masterly Federer himself that "I could not fool him - he seemed to know what shots I was manufacturing and planning - and that was not a good feeling".
But the same goes for the 32-year-old Anderson, who also reached his first Wimbledon quarterfinal, and now semifinal, this week.
The market is finding it hard to split the duo, going [1.97] on Isner to triumph, and I don't think this price on the big American is far from being value. After nearly five hours, I fell down. "I don't want to stop here". "It was great to me to play Rafa in this level".
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Four more young footballers and their coach at the Mu Pa (WIld Boar) Academy Mae Sai , Ekkapol Chantawong, are still on the ledge. In a letter of his own, the coach , Ekapol Chanthawong, apologized to the boys' parents for the ordeal. "The water level is low".
Isner is 33 years old now, a veteran on the ATP Tour.
It was not as if Nadal was playing badly.
"I just kept on telling myself I have to continue believing". "It's true that he played two great points with his serve, but that double fault was a big mistake". Simon failed to convert a break point, then a third match point for Del Potro ended with him netting a forehand. The most important was pushing forward: The Spaniard went to the net a total of 23 times over the first three sets, and upped that to 24 over the last two, winning the point on 19 of those.
Soon enough, del Potro was down on his belly after one last slip, as Nadal finished off the victory with a volley.
John Isner and Kevin Anderson will play in their first Wimbledon semi-final on Friday.
But while Nadal and three-time champion Djokovic were expected to win, and Isner seeded to do so over Raonic, Anderson had never even extracted a set from Federer in four previous meetings.
The roaring Centre Court fans who gave him a standing ovation would not disagree.