The Saudi Arabia, however, will look to keep their World Cup campaign alive, but they'll need to come up with an immensely better play than they had in their tournament opener against the host nation, a 5-0 defeat.
Despite widespread concerns over Russia's quality ahead of the World Cup, the hosts dispatched Saudi Arabia easily on Thursday, running riot over a porous defence to secure a confidence-boosting win.
Teams from the region were hardly alone in experiencing disappointment, but their failure in Russian Federation is especially relevant because the 2022 World Cup will be held in the Middle East for the first time and the performance of Arab sides will be closely scrutinised.
"We have to offer them the tools so on bad days they can overcome that. Each and every player aims at changing the image that we have conveyed because it is not the true image of Saudi football".
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If Uruguay wins today then they move on and Saudi Arabia is out.
Uruguay controlled the game throughout the second half and never looked in doubt of winning the game. If I've learned one thing from being at the World Cup it's that anything can happen. And unusually, Barcelona striker Luis Suarez missed three golden chances to score.
After a dim start to the first half, the Uruguayans had the first sight at goal after Martin Caceres broke out wide and played in a cross for Edinson Cavani, who failed to convert on 12 minutes.
Safah was less complimentary and said that the Saudi players had let their fans down, adding: "They seemed scared whenever they attempted to score any goals".
Queiroz had no complaints about the VAR decision which ruled out Saeid Ezatolahi's strike for offside, preferring instead to rue that it had not been around at the 2010 World Cup when his Portugal were beaten by a contentious Spain goal.
Saudi Arabia have now been eliminated at the group stages in four of the five World Cup Finals they have participated in. The former took on an Egyptian squad missing its star player and escaped with a 1-0 win thanks to a later header goal by Jose Gimenez and despite two missed scoring chances by Luis Suarez.